Prostaglandin D2: the end of a story or just the beginning?
نویسندگان
چکیده
Tremendous progress has been made in the treatment of asthma over past decade. The development monoclonal antibodies against IgE, interleukin-5 (IL-5) or its receptor, IL-4 receptor particular a game changer, for selected group patients. These biologics all target allergic type 2 side spectrum asthma, but even within severe high population these drugs do not completely prevent exacerbations, reducing their frequency by around 40–60%. Additionally, they must be administered intravenously subcutaneously, and are costly. In short, there multiple reasons expanding range options patients with asthma. Effectiveness fevipiprant exacerbations (LUSTER-1 LUSTER-2): two phase 3 randomised controlled trialsAlthough neither trial showed statistically significant reduction after adjusting testing, consistent modest reductions rates were observed both studies 450 mg dose fevipiprant. Full-Text PDF
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ژورنال
عنوان ژورنال: The Lancet Respiratory Medicine
سال: 2021
ISSN: ['2213-2619', '2213-2600']
DOI: https://doi.org/10.1016/s2213-2600(20)30449-5